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Genotropin is presented as a 2-compartment cartridge in a reconstitution device (kabi vial). The front part content recombinant somatropin 16 IU, glycine 2 mg, mannitol 41 mg, sodium dihydrogen phosphate anhydrous 0.29 mg and disodium phosphate 0.28 mg; and the rear part content m-cresol 3 mg and water for injection to 1 mL with reconstitution device.
When the cartridge is screwed together, the injection substance and solvent are automatically mixed.
Somatropin, a human growth hormone, is produced by recombinant DNA technology. Contents and sequence of amino acids are identical with human hypophyseal growth hormone.
Somatropin is synthesized in E. coli bacteria. The synthesis takes place via a prehormone consisting of growth hormone linked to a signal peptide occurring naturally in the bacterium. The prehormone is split in the inner cell wall of the bacterium, releasing growth hormone into the periplasmic space. Growth hormone is then harvested through careful disruption of the outer cell wall of the bacterium. The inner cell wall remains in principle intact.
